Publications

1. Teuchner B, Schmid E, Ulmer H, Gottardi W, Nagl M. Tolerability of N-chlorotaurine plus ammonium chloride in the rabbit and human eye – a phase 1 clinical study. Graefes Arch Clin Exp Ophthalmol 2008.



2. Huber J, Winter P, Gottardi W, Scholl-Burgi S, Prokop W, Nagl M. Tolerability of N-chlorotaurine in the bovine mammary gland. Journal of Dairy Research 2008; 75: 248-256.



3. Furnkranz U, Nagl M, Gottardi W, Kohsler M, Aspock H, Walochnik J. Cytotoxic Activity of N-Chlorotaurine on Acanthamoeba spp. Antimicrob Agents Chemother 2008; 52: 470-476.



4. Gottardi W, Arnitz R, Nagl M. N-Chlorotaurine and ammonium chloride: An antiseptic preparation with strong bactericidal activity. Int. J. Pharmaceut.2007; 335: 32-40.



5. Romanowski EG, Yates KA, Teuchner B, Nagl M, Irschick EU, Gordon YJ. N-Chlorotaurine is and Effective Antiviral Agent against Adenovirus In Vitro and in the Ad5/NZW Rabbit Ocular Model. Invest Ophth Vis Sci. 2006; 47: 2021-2026.



6. Arnitz R, Sarg B, Ott H, Neher A, Linder H, Nagl M. Protein sites of attack of N-Chlorotaurine in Escheria coli.Proteomics 2006; 6, 865-869.



7. Arnitz R, Ott HW, Gstottner M, Nagl M, Scholtz AW, Neher A. A novel N-chlorotaurine-corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro. Acta Oto-Laryngologica 2006; 126: 291-294.



8. 4. Neher A, Fischer H, Appenroth E, Lass-Florl C, Mayr A, Gschwendtner A, Ulmer H, Gotwald T, Gstottner M, Kozlov V, Nagl M. Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter. Auris Nasus Larynx 2005; 32: 359-364.



9. 5. Teuchner B, Nagl M, Schidlbauer A, Ishiko H, Dragosits E, Ulmer H, Aoki K, Ohno S, Mizuki N, Gottardi W, Larcher C. Tolerability and efficacy of N-chlorotaurine in epidemic keratoconjunctivitis – a double-blind randomized phase 2 clinical trial. J Ocular Pharmacol Ther 2005; 21: 157–165.



10. 6. Gottardi W, Nagl M. Chlorine Covers on Living Bacteria: The Initial Step in Antimicrobial Action of Active Chlorine Compounds. J Antimicrob Chemother 2005; 55, 475-482.



11. 7. Gottardi W, Hagleitner M, Nagl M. N, N-Dichlorotaurine: Chemical and Bacterial Properties. Arch. Pharm. Chem. Life Sci. 2005; 338, 473-483.



12. Neher A, Nagl M, Prieskorn D, Mitchell A, Brown N, Schrott-Fischer A, Miller JM. Tolerability of N-chlorotaurine in the guinea pig middle ear - a pilot study using an improved application system. Ann Otol Rhino Larygol 2004; 113: 76-81.



13. Neher A, Nagl M, Appenroth E, Gstöttner M, Wischatta M, Reisigl F, Schindler M, Ulmer H, Stephan K, Acute Otitus Externa: Efficacy and Tolerability of N-Chlorotaurine, a Novel Endogenous Antiseptic Agent. Laryngoscope 2004; 114: 850-854.



14. Wirleitner B, Neurauter G, Nagl M, Fuchs D, Down-regulatory effect of N-chlorotaurine or tryptophan degradation and neopterin production in human PBMC. Immunology Letters 2004; 93: 143-149.



15. Neher A, Gstöttner M, Nagl M, Pototschnig C, Thumfart W. Application of N-Chlorotaurine in Rhinosinusitis Complicating Immunosuppression Following Heart-Transplantation. ORL J Otorhinolaryngol Relat Spec 2003; 65: 303-305



16. Hofer E, Neher A, Gunkel AR, Nagl M. Influence of N-Chlorotaurine on the Ciliary Beat Frequency of Nasal Mucosa. Am J Rhinol 2003; 17: 149-152.



17. Nagl M, Nguyen VA , Gottardi W, Ulmer H, Höpfl R. Tolerability and efficacy of N-chlorotaurine in comparison with chloramine T for treatment of chronic leg ulcers with a purulent coating: a randomized phase II study. British Journal of Dermatology 2003; 149: 590-597.



18. Gottardi W, Nagl M. Chemical properties of N-chlorotaurine sodium, a key compound in the human defence system. Arch Pharm (Weinheim) 2002; 335: 411-421.



19. Nagl M, Gruber A, Fuchs A, Lell C, Lemberger EM, Borg-von Zepelin M, Wuerzner R. Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp. Antimicrob Agents Chemother 2002; 46: 1996-1999.



20. Gottardi W, Hagleitner M, Nagl M. The influence of plasma on the disinfecting activity of the new antimicrobial agent N-chlorotaurine sodium. J Pharm Pharmacol 2001; 53: 689-697.



21. Nagl M, Lass-Floerl C, Neher A, Gunkel AR, Gottardi W. Enhanced fungicidal activity of N-chlorotaurine in nasal secretion. J Antimicrob Chemother 2001; 47: 871-874.



22. Neher A, Nagl M, Schrott-Fischer A, Ichiki H, Gottardi W, Gunkel AR, Stephan K. N-chlorotaurine, a novel endogenous antimicrobial agent: tolerability tested in a mouse model. Arch Otolaryng Head Neck Surg 2001; 127: 530-533.



23. Nagl M, Teuchner B, Pöttinger E, Ulmer H, Gottardi W. Tolerance of N-chlorotaurine, a new antimicrobial agent, in infectious conjunctivitis - a phase II pilot study. Ophthalmologica 2000; 214: 111-114.



24. Nagl M, Hess M, Pfaller K, Hengster P, Gottardi W. Bactericidal activity of micromolar N-chlorotaurine - evidence for its antimicrobial function in the human defence system. Antimicrob Agents Chemother 2000; 44: 2507-2513.



25. Nagl M, Hengster P , Semenitz E, Gottardi W . The postantibiotic effect of N-chlorotaurine on Staphylococcus aureus. Application in the mouse peritonitis model. J Antimicrob Chemother 1999; 43: 805-809.



26. Nagl M, Gottardi W . Rapid killing of Mycobacterium terrae by N-chlorotaurine in presence of ammonium is caused by the reaction product monochloramine. J Pharm Pharmacol 1998; 50: 1317-1320.



27. Nagl M, Pfausler B , Schmutzhard E, Fille M , Gottardi W. Tolerance and bactericidal action of N-chlorotaurine in a urinary tract infection by an omniresistant Pseudomonas aeruginosa. Zent bl Bakteriol 1998; 288: 217-223.



28. Nagl M, Miller B, Daxecker F, Ulmer H, Gottardi W. Tolerance of N-chlorotaurine, an endogenous antimicrobial agent, in the rabbit and human eye - a phase I clinical study. J Ocular Pharmacol Ther 1998; 14: 285-292.



29. Nagl M, Larcher C, Gottardi W. Activity of N-chlorotaurine against herpes simplex- and adenoviruses. Antivir Res 1998; 38: 25-30.



30. Nagl M, Gottardi W . Enhancement of the bactericidal efficacy of N-chlorotaurine by inflammation samples and selected N-H compounds. Hyg Med 1996; 21: 597-605.



31. Nagl M, Gottardi W . In vitro experiments on the bactericidal action of N-chlorotaurine. Hyg Med 1992; 17: 431-439.



32. Nagl M. N-Chlorotaurine als Bestandteil des menschlichen Abwehrsystems: In vitro Experimente zur oxidativen und bakteriziden Wirkung. Thesis. Institute for Hygiene, University of Innsbruck / Austria; 1991.

COPIES OF ALL PUBLICATIONS ARE AVAILABLE UPON REQUEST.